Vitamin D Toxicity; Stored and Released from Adipose Tissue?

نویسندگان

  • Hossein Ziaie
  • Sara Razmjou
  • Rohollah Jomhouri
  • Arya Jenabi
چکیده

Vitamin D is a pro-hormone that plays an important role in body calcium regulation. Vitamin D toxicity occurs rarely due to its wide therapeutic index. A 38-year-old Iranian man was admitted to our hospital with a diagnosis of vitamin D toxicity. Laboratory test revealed hypercalcemia and elevated 25-hydroxyvitamin D (25(OH)D) level. Despite the cessation of vitamin D intake and diuretic treatment, he presented four months later with high 25(OH)D level and similar clinical features. Due to the potential release of vitamin D from adipose tissue, serial monitoring of 25(OH)D level is recommended.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Aerobic Training, Vitamin D, and Injection of Adipose Tissue-Derived Stem Cells on Some Apoptotic and Anti-Apoptotic Indices of Beta-Pancreatic Cells in Diabetic Rats

Background and purpose: Apoptosis is a protective cellular process that plays an important role in the development and homeostasis of natural tissues as well as disease-causing factors. Current study aimed at determining the effect of aerobic training, Vitamin D, and injection of adipose tissue-derived stem cells (ADSCs) on some apoptotic and anti-apoptotic indices of beta-pancreatic cells of s...

متن کامل

The interplay between nutrients and the adipose tissue.

The importance of adipose tissue in health as well as disease has been demonstrated in several studies recently, and it has become appropriate to use the term 'adipose organ' when referring to adipose tissue as a whole. The obesity epidemic, with a marked increase in the incidence of the metabolic syndrome leading to diabetes type 2 as well as cardiovascular complications, has stimulated consid...

متن کامل

Rat adipose tissue rapidly accumulates and slowly releases an orally-administered high vitamin D dose.

We investigated the effect of oral high-dose cholecalciferol on plasma and adipose tissue cholecalciferol and its subsequent release, and on plasma 25-hydroxyvitamin D (25(OH)D). Female Wistar rats (n 126) received 37.5 micrograms cholecalciferol/d for 14 d and were subsequently studied for a further 88 d. Two subgroups of eighteen rats each were fasted for 3 d immediately after treatment (days...

متن کامل

Pharmacokinetics of vitamin D toxicity.

Although researchers first identified the fat-soluble vitamin cholecalciferol almost a century ago and studies have now largely elucidated the transcriptional mechanism of action of its hormonal form, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], we know surprisingly little about mechanisms of vitamin D toxicity. The lipophilic nature of vitamin D explains its adipose tissue distribut...

متن کامل

Comparison of Adipose tissue fatty acide in CAD and non-CAD patients

since long term dietary fatty acide intake is reflected in the fatty acide composition of  Adipose tissue, this study was aimed to compare the adippose tissue fatty acide profile of angiography documented CAD (test)and non-CAD(control)  patients.the first group were 25 patients who underwent coronary artery bypass graft surgery in open heart surgery section of Shahid Beheshti hospital of Kerman...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Archives of Iranian medicine

دوره 19 8  شماره 

صفحات  -

تاریخ انتشار 2016